St. Louis – (June 12, 2017) Today scientists from St. Louis-based Intact Genomics, a world leader of research and services around large DNA fragment cloning and metagenomics related technologies; the University of Wisconsin – Madison; and Northwestern University, announced that their research to develop a new, scalable platform that harvests valuable lead compounds from fungi, using a technology known as Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS) was published by the Nature Chemical Biology. For the article please click here.
The FAC-MS approach harnesses fungi to create powerful molecules honed through evolution by capturing large swaths of their DNA in a special system for robust production and identification of new molecules. Most notable, the company has also developed another disruptive technology of soil shuttle BAC-NGS (next generation sequencing) to capture 100-kb large DNA directly from soil and environmental uncultivable microbes for large-scale natural product discovery.
The new 100-kb large DNA platforms will transform the process of discovering new bioactive molecules for application to numerous human diseases through the systematic discovery of new drug leads from the microbial world.
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